English Name |
Anti-PYCARD Polyclonal Antibody |
Chinese Name |
包含PYD和CARD结构域蛋白抗体 |
Target |
PYCARD |
Synonym |
TMS1, Apoptosis associated speck like protein containing a CARD, Apoptosis-associated speck-like protein containing a CARD, ASC_HUMAN, CARD 5, CARD5, Caspase recruitment domain containing protein 5, Caspase recruitment domain protein 5, Caspase recruitment domain-containing protein 5, hASC, MGC10332, PYCARD, TMS-1, PYD and CARD domain containing, PYD and CARD domain containing protein, PYD and CARD domain-containing protein, Target of methylation induced silencing 1, Target of methylation-induced silencing 1, TMS 1 |
Backgroud |
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. |
Swiss Prot |
Q9ULZ3 |
Gene ID |
29108 |
Subcellular Localization |
Cytoplasm Endoplasmic reticulum Mitochondrion Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
22kDa |
Dilution Ratio |
WB 1:500-1000. IHC 1:50-200. IF 1:50-200. |
Immunogen |
A synthetic peptide of human PYCARD |
Public Immunogen Range |
1-50aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Mouse Rat |
Application |
WB IHC IF |
Specification |
50ul 100ul |