English Name |
Anti-ACTN1 Polyclonal Antibody |
Chinese Name |
肌动蛋α1抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:500-1000. IHC 1:50-200 |
Target |
ACTN1 |
Synonyms |
ACTN 1, ACTN1_HUMAN, Alpha Actinin 1, Alpha actinin cytoskeletal isoform, Alpha-actinin cytoskeletal isoform, Alpha-actinin-1, FLJ40884, FLJ54432, Actinin Alpha 1, F-Actin Cross-Linking Protein, Non-Muscle Alpha-Actinin-1, Actinin, Alpha 1, Actinin 1 Smooth Muscle, BDPLT15 |
Background |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. |
Swiss Prot |
P12814 |
Gene ID |
87 |
Subcellular Location |
Cell junction Cell membrane Cell projection Cytoplasm Z line cytoskeleton myofibril ruffle sarcomere |
Immunogen |
Recombinant protein of human ACTN1 |
Public Immunogen Range |
1-330aa |
Calculated MW |
103kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Mouse Human |
Application |
IHC WB |