English Name |
Anti-ABCB1 Polyclonal Antibody |
Chinese Name |
多药耐药蛋白/P-糖蛋白抗体 |
Target |
ABCB1 |
Synonym |
ABC20, ABCB1, ATP binding cassette, sub family B (MDR/TAP), member 1, ATP-binding cassette sub-family B member 1, CD243, CLCS, Colchicin sensitivity, Doxorubicin resistance, GP170, MDR1, MDR1_HUMAN, Multidrug resistance 1, Multidrug resistance protein 1, P glycoprotein 1, P gp, P-glycoprotein 1, PGY1 |
Backgroud |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. |
Swiss Prot |
P08183 |
Gene ID |
5243 |
Subcellular Localization |
Cell membrane Multi-pass membrane protein |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
141kDa |
Dilution Ratio |
WB 1:500-1000. |
Immunogen |
Recombinant protein of human ABCB1 |
Public Immunogen Range |
603-692aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Mouse |
Application |
WB |
Specification |
50ul 100ul |