English Name |
Anti-PML Polyclonal Antibody |
Chinese Name |
早幼粒细胞白血病蛋白抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:500-2000.IHC 1:50-200 |
Target |
PML |
Synonyms |
PML Protein, MYL, PML, PML_HUMAN, PP8675, Probable transcription factor PML, Promyelocytic leukemia, Promyelocytic leukemia inducer of, Promyelocytic leukemia protein, Protein PML, RING finger protein 71, RNF 71, RNF71, TRIM 19, TRIM19, Tripartite motif containing protein 19, Tripartite motif protein TRIM19, Tripartite motif-containing protein 19 |
Background |
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. |
Swiss Prot |
P29590 |
Gene ID |
5371 |
Subcellular Location |
Cytoplasm Cytoplasmic side Early endosome membrane Endoplasmic reticulum membrane Nucleus PML body Peripheral membrane protein nucleolus nucleoplasm |
Immunogen |
Recombinant protein of human PML |
Public Immunogen Range |
300-600aa |
Calculated MW |
98kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human |
Application |
IHC WB |