English Name |
Anti-CDC42 Polyclonal Antibody |
Chinese Name |
细胞分裂周期蛋白42抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:500-1000. IHC 1:50-200. IF 1:50-200. |
Target |
CDC42 |
Synonyms |
CDC 42, CDC42Hs, Cell division control protein 42 homolog, Cell division cycle 42, Cell division cycle 42 isoform 1, Cell division cycle 42 isoform 2, dJ224A6.1.1, dJ224A6.1.2, G25K, G25K GTP binding protein, Growth regulating protein, GTP binding protein 25kD, Small GTP binding protein CDC42, CDC42_HUMAN |
Background |
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. |
Swiss Prot |
P60953 |
Gene ID |
998 |
Subcellular Location |
Cell membrane Cytoplasm Cytoplasmic side Lipid-anchor Midbody centrosome cytoskeleton microtubule organizing center spindle |
Immunogen |
Recombinant protein of human CDC42 |
Public Immunogen Range |
118-191aa |
Calculated MW |
21kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Rat Mouse Human |
Application |
IF IHC WB |