Anti-FAS Polyclonal Antibody_Primary Antibodies_Antibodies_Solarbio-Global Leader in Antibody and Elisa Kit

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
K002531P-100ul	Inquiry	Inquiry	Inquiry	Inquiry
K002531P-50ul	Inquiry	Inquiry	Inquiry	Inquiry

English Name	Anti-FAS Polyclonal Antibody
Chinese Name	肿瘤坏死因子受体超家族成员6抗体
Target	FAS
Synonym	ALPS1A;APO-1;APT1;CD95;FAS1;FASTM;TNFRSF6
Backgroud	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Swiss Prot	P25445
Gene ID	355
Subcellular Localization	Cell membrane Secreted Single-pass type I membrane protein
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Protein MW	38kDa
Dilution Ratio	WB 1:500-1000. IF 1:50-100.
Immunogen	Recombinant protein of human FAS
Public Immunogen Range	30-335aa
Purification Method	Affinity purification
Storage Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage	Store at -20℃, avoid freeze/thaw cycles.
Unit	Piece
Cross-Reactivity	Human
Application	WB IF
Specification	50ul 100ul