English Name |
Anti-HEXA Polyclonal Antibody |
Chinese Name |
己糖胺酶A(α多肽)抗体 |
Target |
HEXA |
Synonym |
Beta hexosaminidase alpha chain precursor, Beta hexosaminidase subunit alpha, Beta N acetylhexosaminidase, Beta N acetylhexosaminidase subunit alpha, Beta-hexosaminidase subunit alpha, Beta-N-acetylhexosaminidase subunit alpha, Hexa, HEXA_HUMAN, Hexosaminidase A (alpha polypeptide), Hexosaminidase A alpha polypeptide, Hexosaminidase A, Hexosaminidase subunit A, MGC99608, N acetyl beta glucosaminidase, N acetyl beta glucosaminidase subunit alpha, N-acetyl-beta-glucosaminidase subunit alpha, TSD |
Backgroud |
This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. |
Swiss Prot |
P06865 |
Gene ID |
3073 |
Subcellular Localization |
Lysosome |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
61kDa |
Dilution Ratio |
WB 1:500-2000. IHC 1:50-200. |
Immunogen |
Recombinant protein of human HEXA |
Public Immunogen Range |
270-529aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Mouse Rat |
Application |
WB IHC |
Specification |
50ul 100ul |