English Name |
Anti-GHRL Polyclonal Antibody |
Chinese Name |
食欲调节激素抗体 |
Target |
GHRL |
Synonym |
Appetite regulating hormone, Ghrelin 27, Ghrelin 28, Ghrelin/obestatin prepropeptide, GHRL, Growth hormone releasing peptide, Growth hormone secretagogue, M46 protein, Motilin related peptide, MTLRP, Obestatin, Obestatin preprohormone, PRO1066, UNQ524, GHRL_HUMAN |
Backgroud |
This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. |
Swiss Prot |
Q9UBU3 |
Gene ID |
51738 |
Subcellular Localization |
Secreted |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
13kDa |
Dilution Ratio |
WB 1:500-2000. IHC 1:50-200. |
Immunogen |
Recombinant protein of human GHRL |
Public Immunogen Range |
1-117aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat |
Application |
WB IHC |
Specification |
50ul 100ul |