| English Name |
Anti-KIR2DL4 Polyclonal Antibody |
| Chinese Name |
杀伤细胞免疫球蛋白样受体2DL4抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Dilution Ratio |
WB 1:500-1000. |
| Target |
KIR2DL4 |
| Synonyms |
Killer cell immunoglobulin-like receptor 2DL4, MHC class I NK cell receptor KIR103AS, KIR103, CD158d, CD158 antigen like family member D, CD158D, G9P, Killer cell immunoglobulin like receptor, two domains, long cytoplasmic tail, 4 , Killer cell inhibitory receptor 103AS, KIR 103AS, KIR103AS, NK cell receptor, natural killer cell inhibitory receptor, KI2L4_HUMAN |
| Background |
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. |
| Swiss Prot |
Q99706 |
| Gene ID |
3805 |
| Subcellular Location |
Cell membrane Single-pass type I membrane protein |
| Immunogen |
Recombinant protein of human KIR2DL4 |
| Public Immunogen Range |
22-242aa |
| Calculated MW |
41kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 0.02% sodium azide，50% glycerol，pH7.3. |
| Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Rat Human Mouse |
| Application |
WB |
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