English Name |
Anti-GNB3 Polyclonal Antibody |
Chinese Name |
鸟嘌呤核苷酸结合蛋白(G蛋白)亚基β3抗体 |
Target |
GNB3 |
Synonym |
G protein beta 3, Gnb3, Guanine nucleotide binding protein (G protein), beta polypeptide 3, Guanine nucleotide binding protein G, Hypertension associated protein, IG, SG, Transducin beta chain 3, Tsubunit beta 3, GBB3_HUMAN |
Backgroud |
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. |
Swiss Prot |
P16520 |
Gene ID |
2784 |
Subcellular Localization |
Cytosol secreted Plasma Membrane |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
37kDa |
Dilution Ratio |
WB 1:500-1000. IF 1:50-200. |
Immunogen |
Recombinant protein of human GNB3 |
Public Immunogen Range |
1-340aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IF |
Specification |
50ul 100ul |