English Name |
Anti-FGR Polyclonal Antibody |
Chinese Name |
原癌基因c FGR抗体 |
Target |
FGR |
Synonym |
c fgr, c fgr protooncogene, c src 2 proto oncogene, c src2, Fgr, FGR_HUMAN, FLJ43153, Gardner Rasheed feline sarcoma viral (v fgr), Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, MGC75096, p55 c fgr protein, P55 FGR, P55-FGR, p55c fgr, p58-Fgr, p58c fgr, p58c-Fgr, Proto oncogene c Fgr, Proto oncogene tyrosine protein kinase FGR, Proto-oncogene c-Fgr, SRC 2, SRC2, Tyrosine protein kinase Fgr, Tyrosine-protein kinase Fgr |
Backgroud |
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Swiss Prot |
P09769 |
Gene ID |
2268 |
Subcellular Localization |
Cell membrane Cell projection Cytoplasm Cytoplasmic side Lipid-anchor Mitochondrion inner membrane Mitochondrion intermembrane space Peripheral membrane protein cytoskeleton cytosol ruffle membrane |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
59kDa |
Dilution Ratio |
WB 1:500-2000. IHC 1:50-200. |
Immunogen |
A synthetic peptide of human FGR |
Public Immunogen Range |
1-100aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |