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My CartReactivity：Human,Mouse,Rat
Application：IF,IHC,WB
Clone Type：Polyclonal Antibody
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Gene ID：836
Host：Rabbit
Qty：
Size：
| Name | Anti-CASP3 Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Dilution Ratio | WB 1:1000-5000. IHC 1:50-200. IF 1:50-200. |
| Target | CASP3 |
| Background | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. |
| Swiss Prot | P42574 |
| Gene ID | 836 |
| Subcellular Location | Cytoplasm |
| Immunogen | Recombinant protein of human CASP3 |
| Public Immunogen Range | 55-160aa |
| Calculated MW | 32kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide，50% glycerol，pH7.3. |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Unit | Piece |
| Specification | 50ul 100ul |
| Reactivity | Human Mouse Rat |
| Application | IF IHC WB |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Western blot analysis with CASP3 antibody diluted at 1:1000;Lane: 293T.
Immunohistochemistry of paraffin-embedded rat spleen with CASP3 antibody diluted at 1:100.
Immunofluorescence analysis of NIH3T3 cells using CASP3 antibody diluted at 1:100.
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Protective effect of low molecular weight peptides from Solenocera crassicornis head against cyclophosphamide-induced nephrotoxicity in mice via the Keap1/Nrf2 pathway
Click to check >>Author：Jiang S
IF：6.3120
Publish_to：Antioxidants
PMID：32823691
Protective Effect of Low Molecular Weight Peptides from Solenocera crassicornis Head against Cyclophosphamide-Induced Nephrotoxicity in Mice via the Keap1/Nrf2 Pathway
Click to check >>Author：姜烁琦
IF：5.0140
Publish_to：
PMID：32823691
Various detailed characteristics of a new enhanced neurotrophic factor secreting rat derived bone marrow mesenchymal stem cells and its preliminary application in rat models of ischemic stroke
Click to check >>Author：Jiang F
IF：3.9050
Publish_to：Experimental Cell Research
PMID：35436472
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