English Name |
Anti-NF2 Polyclonal Antibody |
Chinese Name |
神经纤维瘤蛋白2抗体 |
Target |
NF2 |
Synonym |
neurofibromatosis type 2, CAN, BANF, bilateral acoustic neuroma, moesin ezrin radixin like protein, Moesin ezrin radizin like protein, merlin, Neurofibromatosis 2, ACN, Bilateral acoustic neuroma, MERL_HUMAN, Merlin, Moesin ezrin radizin like, Moesin-ezrin-radixin-like protein, Neurofibromatosis type 2, Neurofibromin-2, NF 2, Nf2, Neurofibromatosis2, Neurofibromin 2, Neurofibromin2, Schwannomerlin, NF-2, SCH, Schwannomin |
Backgroud |
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. |
Swiss Prot |
P35240 |
Gene ID |
4771 |
Subcellular Localization |
Cell projection Cytoplasm Cytoplasmic granule Cytoplasmic side Nucleus Nucleus Peripheral membrane protein cytoskeleton filopodium membrane perinuclear region ruffle membrane |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
70kDa |
Dilution Ratio |
WB 1:500-1000. IP 1:500-1000. |
Immunogen |
Recombinant protein of human NF2 |
Public Immunogen Range |
19-595aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IP |
Specification |
50ul 100ul |