English Name |
Anti-FUBP1 Polyclonal Antibody |
Chinese Name |
DNA解旋酶V抗体 |
Target |
FUBP1 |
Synonym |
FBP1, DNA helicase V, far upstream element (FUSE) binding protein 1, Far upstream element (FUSE) binding protein 4, Far upstream element binding protein 1, far upstream element binding protein, Far upstream element-binding protein 1, FBP, FUBP, Fubp1, FUBP1_HUMAN, Fubp4, FUSE binding protein 1, FUSE-binding protein 1, HDH V |
Backgroud |
The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. |
Swiss Prot |
Q96AE4 |
Gene ID |
8880 |
Subcellular Localization |
Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
68kDa |
Dilution Ratio |
WB 1:500-2000.IHC 1:50-200.IF 1:50-100.IP 1:50-100 |
Immunogen |
Recombinant protein of human FUBP1 |
Public Immunogen Range |
302-644aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IHC IF IP |
Specification |
50ul 100ul |