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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
K004551P-100ul	Inquiry	Inquiry	Inquiry	Inquiry
K004551P-50ul	Inquiry	Inquiry	Inquiry	Inquiry

English Name	Anti-PTRH2 Polyclonal Antibody
Chinese Name	肽基tRNA水解酶2抗体
Target	PTRH2
Synonym	BIT1;CFAP37;CGI-147;IMNEPD;PTH;PTH 2;PTH2
Backgroud	The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms.
Swiss Prot	Q9Y3E5
Gene ID	51651
Subcellular Localization	Mitochondrion
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Protein MW	19kDa
Dilution Ratio	WB 1:500-2000. IHC 1:50-200. IF 1:10-100.
Immunogen	Recombinant protein of human PTRH2
Public Immunogen Range	40-179aa
Purification Method	Affinity purification
Storage Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage	Store at -20℃, avoid freeze/thaw cycles.
Unit	Piece
Cross-Reactivity	Human Mouse Rat
Application	WB IHC IF
Specification	50ul 100ul