English Name |
Anti-CD177 Polyclonal Antibody |
English Name |
Anti-CD177 Polyclonal Antibody |
Chinese Name |
CD177蛋白抗体 |
Chinese Name |
CD177蛋白抗体 |
Target |
CD177 |
Synonym |
HNA-2a;HNA2A;NB1;NB1 GP;PRV-1;PRV1
|
Host |
Rabbit |
Backgroud |
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. |
Clone Type |
Polyclonal Antibody |
Swiss Prot |
Q8N6Q3 |
Subtype |
IgG |
Gene ID |
57126 |
Subcellular Localization |
Cell membrane Cell projection Membrane Secreted |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Dilution Ratio |
WB 1:500-1000. |
Subtype |
IgG |
Protein MW |
46kDa |
Dilution Ratio |
WB 1:500-1000. |
Immunogen |
Recombinant protein of human CD177 |
Public Immunogen Range |
35-285aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Target |
CD177 |
Synonyms |
HNA-2a;HNA2A;NB1;NB1 GP;PRV-1;PRV1 |
Background |
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. |
Swiss Prot |
Q8N6Q3 |
Gene ID |
57126 |
Subcellular Location |
Cell membrane Cell projection Membrane Secreted |
Immunogen |
Recombinant protein of human CD177 |
Public Immunogen Range |
35-285aa |
Calculated MW |
46kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Unit |
Piece |
Unit |
Piece |
Specification |
100ul |
Application |
WB |
Cross-Reactivity |
Human Mouse |
Application |
WB |
Specification |
50ul 100ul |