English Name |
Anti-PRMT6 Polyclonal Antibody |
Chinese Name |
组蛋白精氨酸甲基转移酶6抗体 |
Target |
PRMT6 |
Synonym |
PRMT 6, PRMT6, ANM6_HUMAN, Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6, HMT1 hnRNP methyltransferase like 6, HRMT1L6, prmt6, Protein arginine methyltransferase 6, Protein arginine N methyltransferase 6, Protein arginine N-methyltransferase 6 |
Backgroud |
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. |
Swiss Prot |
Q96LA8 |
Gene ID |
55170 |
Subcellular Localization |
Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
42kDa |
Dilution Ratio |
WB 1:500-2000. IF 1:50-200. |
Immunogen |
Recombinant protein of human PRMT6 |
Public Immunogen Range |
1-375aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Mouse |
Application |
WB IF |
Specification |
50ul 100ul |