English Name |
Anti-PRKAB1 Polyclonal Antibody |
Chinese Name |
AMP激活蛋白激酶β-1抗体 |
Target |
PRKAB1 |
Synonym |
5 AMP activated protein kinase subunit beta 1, AMPK, AMPK beta 1 chain, AMPKb, HAMPKb, PRKAB1, 5-AMP-activated protein kinase subunit beta-1, AMP-activated protein kinase beta subunit, protein kinase, AMP-activated, noncatalytic, beta-1, AMPK beta -1 chain, 5-AMP-activated protein kinase beta-1 subunit, AMPKb, AMPK subunit beta-1, AAKB1_HUMAN, AMPK b1, AMPK-b1 |
Backgroud |
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. |
Swiss Prot |
Q9Y478 |
Gene ID |
5564 |
Subcellular Localization |
Cytosol Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
30kDa |
Dilution Ratio |
WB 1:500-2000. IHC 1:50-200. |
Immunogen |
A synthetic peptide of human PRKAB1 |
Public Immunogen Range |
100-200aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Mouse Rat |
Application |
WB IHC |
Specification |
50ul 100ul |