English Name |
Anti-FGD4 Polyclonal Antibody |
Chinese Name |
FGD4蛋白抗体 |
Target |
FGD4 |
Synonym |
9030023J02Rik, 9330209B17Rik, Actin filament binding protein frabin, Actin filament-binding protein frabin, CMT4H, DKFZp313E1818, DKFZp434K1572, FGD1 related F actin binding protein, FGD1-related F-actin-binding protein, Fgd4, FGD4_HUMAN, FLJ34370, FLJ42663, FRABP, FYVE, FYVE, RhoGEF and PH domain containing 4, MGC57222, RhoGEF and PH domain-containing protein 4, ZFYVE6, Zinc finger FYVE domain containing protein 6, Zinc finger FYVE domain-containing protein 6 |
Backgroud |
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Swiss Prot |
Q96M96 |
Gene ID |
121512 |
Subcellular Localization |
Cell projection Cytoplasm cytoskeleton filopodium |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
87kDa |
Dilution Ratio |
WB 1:500-2000. IHC 1:50-200. |
Immunogen |
Recombinant protein of human FGD4 |
Public Immunogen Range |
99-198aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Mouse Rat |
Application |
WB |
Specification |
50ul 100ul |