Anti-Phospho-SMC1A-S957 Polyclonal Antibody_Primary Antibodies_Antibodies_Solarbio-Global Leader in Antibody and Elisa Kit

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SKU	Tongzhou Beijing	Haidian Beijing	Wuhan	Guangzhou
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English Name	Anti-Phospho-SMC1A-S957 Polyclonal Antibody
Chinese Name	磷酸化染色体结构维持蛋白质１抗体
Target	Phospho-SMC1A-S957
Synonym	CDLS2;DXS423E;SB1.8;SMC1;SMC1L1;SMC1alpha;SMCB
Backgroud	Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Swiss Prot	Q14683
Gene ID	8243
Subcellular Localization	Chromosome Nucleus centromere kinetochore
Host	Rabbit
Clone Type	Polyclonal Antibody
Subtype	IgG
Protein MW	143kDa
Dilution Ratio	WB 1:500-2000.IHC 1:50-200.IP 1:50-100
Immunogen	A phospho specific peptide corresponding to residues surrounding S957 of human SMC1A
Purification Method	Affinity purification
Storage Buffer	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage	Store at -20℃, avoid freeze/thaw cycles.
Unit	Piece
Cross-Reactivity	Human Rat Mouse
Application	WB IHC IP
Specification	50ul 100ul