English Name |
Anti-PTPRC Monoclonal antibody |
Chinese Name |
白细胞共同抗原CD45 抗体 |
Target |
PTPRC |
Synonym |
B220,CD 45,CD45,cd45 antigen,ec3.1.3.48,CD45R,GP180,GP180,GP 180,L CA,LCA,L-CA,Leukocyte common antigen,LY5,?PTPRC,T200 |
Backgroud |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. |
Swiss Prot |
P08575 |
Gene ID |
5788 |
Subcellular Localization |
Membrane Membrane raft Single-pass type I membrane protein |
Host |
Mouse |
Clone Type |
Monoclonal antibody |
Subtype |
IgG1 |
Clone Number |
1E1-F11-E10 |
Protein MW |
147kDa |
Dilution Ratio |
WB 1:500-1000. IHC 1:100-200. |
Immunogen |
Recombinant protein of human PTPRC |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: Purified antibody in PBS with 0.05% sodium azide |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human |
Application |
WB IHC |
Specification |
50ul 100ul |