English Name |
Anti-DUSP12 Polyclonal Antibody |
Chinese Name |
双特异性磷酸酶12抗体 |
Target |
DUSP12 |
Synonym |
Dual specificity phosphatase 12, Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUS12_HUMAN, DUSP 1, DUSP 12, DUSP1, DUSP12, Serine/threonine specific protein phosphatase, TDSP4, YVH 1, YVH1, YVH1 protein tyrosine phosphatase (S. cerevisiae) ortholog, YVH1 protein tyrosine phosphatase ortholog |
Backgroud |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. |
Swiss Prot |
Q9UNI6 |
Gene ID |
11266 |
Subcellular Localization |
Cytoplasm Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
38kDa |
Dilution Ratio |
WB 1:200-1000. IHC 1:10-100. |
Immunogen |
Recombinant protein of human DUSP12 |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |