English Name |
Anti-NOTCH4 Polyclonal Antibody |
Chinese Name |
跨膜蛋白NOTCH4配体抗体 |
Target |
NOTCH4 |
Synonym |
Notch 4,FLJ16302, hNotch 4, hNotch4, INT 3, INT3, MGC74442, Neurogenic locus notch homolog protein 4, NOTC4_HUMAN, NOTCH 3, NOTCH 4, Notch 4 intracellular domain, Notch homolog 4, NOTCH3, Notch4, NOTCH4 protein, |
Backgroud |
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
Swiss Prot |
Q99466 |
Gene ID |
4855 |
Subcellular Localization |
Cytoplasm |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
210kDa |
Dilution Ratio |
WB 1:800-2000. IHC 1:30-150. |
Immunogen |
A synthetic peptide of human NOTCH4 |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human |
Application |
WB IHC |
Specification |
50ul 100ul |