English Name |
Anti-CDKL1 Polyclonal Antibody |
Target |
CDKL1 |
Synonym |
CDC 2 related kinase 1, CDC 2 related kinase, CDC2 related kinase 1, CDC2 related kinase, CDK L1, CDKL 1, cdkl1, CDKL1_HUMAN, Cyclin dependent kinase like 1, cyclin-dependent kinase-like 1 (CDC2-related kinase), Cyclin-dependent kinase-like 1, EC 2.7.11.22, KKIALRE, p42, Protein kinase p42 KKIALRE, Serine/threonine protein kinase KKIALRE, Serine/threonine-protein kinase KKIALRE |
Backgroud |
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif. |
Swiss Prot |
Q00532 |
Gene ID |
8814 |
Subcellular Localization |
Cytoplasm Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
42kDa |
Dilution Ratio |
WB 1:200-1000. IHC 1:20-100. |
Immunogen |
A synthetic peptide of human CDKL1 |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human |
Application |
WB IHC |
Specification |
50ul 100ul |