English Name |
Anti-DUSP4 Polyclonal Antibody |
Chinese Name |
双特异性磷酸酶4抗体 |
Target |
DUSP4 |
Synonym |
Mitogen activated protein kinase phosphatase 2, Dual specificity phosphatase 4, Dual specificity protein phosphatase 4, Dual specificity protein phosphatase hVH2, DUSP 4, HVH 2, HVH2, MAP kinase phosphatase 2, Mitogen activated protein kinase phosphatase 2, MKP 2, MKP-2, MKP2, Serine/threonine specific protein phosphatase, TYP, VH 2, VH1 homologous phosphatase 2, VH2 |
Backgroud |
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. |
Swiss Prot |
Q13115 |
Gene ID |
1846 |
Subcellular Localization |
Cytoplasm Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
43kDa |
Dilution Ratio |
WB 1:500-2000. IHC 1:50-150. |
Immunogen |
Recombinant protein of human DUSP4 |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |