English Name |
Anti-CALR Polyclonal Antibody |
Chinese Name |
钙网蛋白抗体 |
Target |
CALR |
Synonym |
Autoantigen RO, CALR, CALR protein, CALR_HUMAN, Calregulin, cC1qR, CRP55, CRTC, Endoplasmic reticulum resident protein 60, ERp60, grp60, HACBP, RO, Sicca syndrome antigen A, SSA |
Backgroud |
Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. |
Swiss Prot |
P27797 |
Gene ID |
811 |
Subcellular Localization |
Cell surface Cytoplasm Endoplasmic reticulum lumen Sarcoplasmic reticulum lumen Secreted cytosol extracellular matrix extracellular space |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
48kDa |
Dilution Ratio |
WB 1:1000-5000. IHC 1:50-200. |
Immunogen |
Recombinant protein of human CALR |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |