English Name |
Anti-IDE Polyclonal Antibody |
Chinese Name |
胰岛素降解酶抗体 |
Target |
IDE |
Synonym |
BC2, Insulin degrading enzyme, FLJ35968, insulin protease, insulinase, insulysin, Abeta-degrading protease, FLJ35968, Ide, IDE_HUMAN, Insulin-degrading enzyme, |
Backgroud |
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified. |
Swiss Prot |
P14735 |
Gene ID |
3416 |
Subcellular Localization |
Cell membrane Cytoplasm Secreted |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
118kDa |
Dilution Ratio |
WB 1:500-2000. IHC 1:10-50. |
Immunogen |
Recombinant protein of human IDE |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |