English Name |
Anti-TOP2A Polyclonal Antibody |
Chinese Name |
DNA拓普西异构酶Ⅱ抗体 |
Target |
TOP2A |
Synonym |
DNA topoisomeraseⅡalpha, TOPO II, DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2, TP2A, DNA topoisomerase II 170 kD, DNA topoisomerase II alpha isozyme, DNA Topoisomerase2, TOP 2A, TopII alpha, Topo II alpha, Topoisomerase DNA II alpha 170kDa, Topoisomerase II alpha 170 kDa, TOP2A_HUMAN, Topo IIα, Topo-IIα, Topoisomerase II-α.?? |
Backgroud |
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. |
Swiss Prot |
P11388 |
Gene ID |
7153 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
174/177/182kDa |
Dilution Ratio |
WB 1:2000-5000. IHC 1:25-100. |
Immunogen |
A synthetic peptide of human TOP2A |
Public Immunogen Range |
65-115/1531aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Pig Rat Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |