English Name |
Anti-DLAT Polyclonal Antibody |
Chinese Name |
S-乙酰转移酶二氢脂酰胺抗体 |
Target |
DLAT |
Synonym |
DLAT, DLTA, E2, E2 component of pyruvate dehydrogenase complex, EC 2.3.1.12, M2 antigen complex 70 kDa subunit, M2 Antigen Complex 70kD Subunit, mitochondrial, ODP2_HUMAN, PBC, PDC E2, PDC-E2, PDCE2, Pyruvate dehydrogenase complex component E2, Pyruvate dehydrogenase complex E2 subunit, S acetyltransferase component of pyruvate dehydrogenase complex |
Backgroud |
This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood. |
Swiss Prot |
P10515 |
Gene ID |
1737 |
Subcellular Localization |
Cytoplasm |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
69 kDa |
Dilution Ratio |
WB 1:500-2000.IHC 1:30-150 |
Immunogen |
Recombinant protein of human DLAT |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |