English Name |
Anti-ADORA2A Polyclonal Antibody |
Chinese Name |
腺苷A2b受体/神经生长因子1受体抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
IHC 1:25-100. |
Target |
ADORA2A |
Synonyms |
Adenosine Receptor A2a,Adenosine A2A-R,A2AR,A2A adenosine receptor,A2AAR,A2aR,ADENO,Adenosine A2 receptor,Adenosine A2a receptor,Adenosine receptor subtype A2a,Adenosine Receptor A2a,ADORA 2,ADORA2,Adora2a,hA2aR,RDC 8,RDC8,AA2AR_HUMAN |
Background |
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. |
Swiss Prot |
P29274 |
Gene ID |
135 |
Subcellular Location |
Cell membrane Multi-pass membrane protein |
Immunogen |
A synthetic peptide of human ADORA2A |
Calculated MW |
45kDa |
Purification Method |
Affinity purification |
Storage Buffer |
pH7.4 PBS,0.05% NaN3,40% Glycerol. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Unit |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human |
Application |
IHC |