English Name |
Anti-MTA2 Polyclonal Antibody |
Chinese Name |
转移相关蛋白2抗体 |
Target |
MTA2 |
Synonym |
Mata1l1, Metastasis associated 1 family member 2, Metastasis associated 1 like 1, Metastasis associated gene 1 like 1, Metastasis associated gene family member 2, Metastasis associated protein 2, Metastasis associated protein MTA 2, Metastasis associated protein MTA2, Mmta2, MTA1 L1 protein, MTA1-L1 protein, MTA1L1, MTA1L1: metastasis-associated 1-like 1, P53 target protein in deacetylase complex, PID, MTA2_HUMAN |
Backgroud |
This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. |
Swiss Prot |
O94776 |
Gene ID |
9219 |
Subcellular Localization |
Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
75 kDa |
Dilution Ratio |
WB 1:500-2000.IHC 1:25-100. |
Immunogen |
A synthetic peptide of human MTA2 |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |