CAS:480-41-1
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:HPLC≥98%
Appearance:White to yellow Solid
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NaringeninCAS:480-41-1
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:HPLC≥98%
Appearance:White to yellow Solid
CAS | 480-41-1 |
Chinese Name | 柚皮素 |
English Name | Naringenin |
Synonyms | NSC 34875;S-Dihydrogenistein;NSC 11855;Salipurol;Salipurol;Pelargidanon; |
Molecular Formula | C15H12O5 |
Molecular Weight | 272.25 |
Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Ethanol ≥10mg/mL;Soluble in Water <1mg/mL |
Purity | HPLC≥98% |
Appearance | White to yellow Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC | EINECS 266-769-1 |
MDL | MFCD00006844 |
SMILES | O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13 |
InChIKey | FTVWIRXFELQLPI-ZDUSSCGKSA-N |
InChI | InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1 |
PubChem CID | 439246 |
Target Point | Others |
Passage | Others |
Background | Naringenin is a flavanone with anti-inflammatory and antioxidant activities, which can be used for antioxidant, free radical scavengers, anti-inflammatory agents, carbohydrate metabolism promoters, immune system modulators and other related research. |
Biological Activity | Naringenin是葡萄柚中主要的黄烷酮; 显示出强烈的抗炎和抗氧化活性。[1-5] |
In Vitro | 柚皮素显示抑制HepG2细胞的增殖,部分原因是细胞周期的G0 / G1期和G2 / M期细胞积聚。已经证明柚皮素可以诱导细胞凋亡,这可以通过细胞核损伤和凋亡细胞比例增加来证明。 Naringenin触发线粒体介导的细胞凋亡途径,如Bax / Bcl-2比例增加,随后细胞色素C释放和caspase-3顺序激活所示[1]。柚皮素暴露显着降低A431细胞的细胞活力,同时以剂量依赖性方式伴随核浓缩和DNA片段化的增加。细胞周期研究表明,柚皮素诱导细胞周期G0 / G1期细胞周期停滞,caspase-3分析显示caspase-3活性呈剂量依赖性增加,导致细胞凋亡[2]。 |
In Vivo | 柚皮素补充剂导致血浆和肝脏中总甘油三酯和胆固醇的量显着减少。此外,柚皮素补充剂可降低宫旁脂肪组织中的肥胖和甘油三酯含量。柚皮素喂养的动物显示肝脏中PPARα蛋白表达显着增加。已知受PPARα调节的CPT-1和UCP2的表达通过柚皮素治疗显着增强[3]。柚皮素通过PPARγ辅激活因子1α/PPARα介导的转录程序增加肝脏脂肪酸氧化。它通过减少空腹高胰岛素血症来预防甾醇调节元件结合蛋白1c介导的肝脏和肌肉脂肪生成。柚皮素可降低肝脏胆固醇和胆固醇酯的合成[4]。柚皮素以剂量依赖性方式抑制TNF-α诱导的VSMC增殖和迁移。机理研究表明,柚皮素可阻止ERK / MAPK和Akt磷酸化,同时保持p38 MAPK和JNK不变。柚皮素还可以阻断TNF-α诱导的ROS生成[5]。 |
Cell Experiment | 将柚皮素溶解在DMSO中并在细胞培养基中稀释。用PBS冲洗细胞并在含有各种浓度的柚皮素(50,100,150,200,250,300μM)的培养基中生长。溶剂DMSO处理的细胞用作对照。处理24小时后,除去培养基并用含有MTT的另一种培养基替换。使用MTT测定法测量细胞活力[1]。 |
Animal Experiment | 大鼠:制备半纯化的粉末饮食,用于浓度为柚皮素:0,0.003,0.006和0.012%的饮食。适应7天后,将大鼠分成四组中的一组,每组六只动物,并喂食半纯化的实验饮食6周。实验饮食含有16%脂肪,45.5%蔗糖和不同的柚皮素浓度(0,0.003,0.006或0.012%)(表1)。在研究期间,大鼠可随意获取食物和水。在整个实验过程中测量食物摄入量和体重[3]。小鼠:8至12周龄的小鼠随意喂食啮齿动物标准饮食或含有42%来自脂肪加胆固醇(0.05%wt / wt)的卡路里的高脂肪饮食。柚皮素以1%或3%(wt / wt)加入西方饮食中。 Ldlr - / - 小鼠喂养4周,C57BL / 6J小鼠喂养30周。每天测量食物摄入量,每两周测量一次体重。在干预前将小鼠禁食6小时[4]。 |
Data Literature Source | [1]. Arul D, et al. Naringenin (citrus flavonone) induces growth inhibition, cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. Pathol Oncol Res. 2013 Oct; 19 (4) :763-70. [2]. Ahamad MS, et al. Induction of apoptosis and antiproliferative activity of naringenin in human epidermoid carcinomacell through ROS generation and cell cycle arrest. PLoS One. 2014 Oct 16; 9 (10) :e110003. [3]. Cho KW, et al. Dietary naringenin increases hepatic peroxisome proliferators-activated receptor α proteinexpression and decreases plasma triglyceride and adiposity in rats. Eur J Nutr. 2011 Mar; 50 (2) :81-8. [4]. Mulvihill EE, et al. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDLreceptor-null mice with diet-induced insulin resistance. Diabetes. 2009 Oct; 58 (10) :2198-210. [5]. Chen S, et al. Naringenin inhibits TNF-α induced VSMC proliferation and migration via induction of HO-1. Food Chem Toxicol. 2012 Sep; 50 (9) :3025-31 |
Unit | Bottle |
Specification | 20mg 10mM*1mL in DMSO 50mg 100mg |