English Name |
Anti-PFKFB3 Polyclonal Antibody |
Chinese Name |
6-磷酸果糖-2-激酶/果糖-2, 6-二磷酸酶3抗体 |
Target |
PFKFB3 |
Synonym |
6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase, 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3, 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme, 6PF 2-K/Fru 2,6 P2ase 3, fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase, Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase, iPFK 2, IPFK2, PFK/FBPase 3, PFK-2, PFK2, Renal carcinoma antigen NY REN 56, uPFK 2, PFKFB3, F263_HUMAN |
Backgroud |
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Swiss Prot |
Q16875 |
Gene ID |
5209 |
Subcellular Localization |
Cytosol Nucleus |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Protein MW |
60kDa |
Dilution Ratio |
WB 1:100-500. IHC 1:50-200. |
Immunogen |
Recombinant protein of human PFKFB3 |
Public Immunogen Range |
130-220aa |
Purification Method |
Affinity purification |
Storage Buffer |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
Storage |
Store at -20℃, avoid freeze/thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human Rat Mouse |
Application |
WB IHC |
Specification |
50ul 100ul |