| CAS |
556-27-4 |
| Chinese Name |
蒜氨酸 |
| English Name |
Alliin |
| Synonyms |
S-allyl cysteine sulfoxide;ACSO;3-(Allylsulphinyl)-L-alanine;(S)-3-(Allylsulphinyl)-L-alanine |
| Molecular Formula |
C6H11NO3S |
| Molecular Weight |
177.22 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
Einecs 209-118-9 |
| MDL |
MFCD01311056 |
| SMILES |
N[C@@H](C[S@](CC=C)=O)C(O)=O |
| InChIKey |
XUHLIQGRKRUKPH-ITZCMCNPSA-N |
| InChI |
InChI=1S/C6H11NO3S/c1-2-3-11(10)4-5(7)6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-,11?/m0/s1 |
| PubChem CID |
87310 |
| Target Point |
Others |
| Passage |
Others |
| Background |
It is a unique non-protein sulfur-containing amino acid in a class of garlic. |
| Biological Activity |
Alliin， the most abundant sulphur compound in garlic， has been demonstrated to exhibit hypoglycemic， antioxidant and anti-inflammatory activities. Alliin was effective on attenuating 1，3-DCP-induced lipogenesis via activation of the AMPK-SREBPs signaling pathway in HepG2 cells.[1] |
| In Vitro |
Alliin attenuated lipogenesis induced by 1，3-DCP and that the reduction was due to activation of the AMPK pathway. HepG2 cells exposed to 1，3-DCP exhibited significant increase of triglyceride(TG)and total cholesterol(TC)，and alliin reduced the accumulation. Most importantly，alliin could up-regulate the phosphorylation of AMPK and down-regulate protein and gene expressions of SREBP-1; FAS; SREBP-2;HMGCR in 1，3-DCP-induced HepG2 cells. [1] |
| In Vivo |
Alliin ameliorates DSS-induced ulcerative colitis and inhibits the inflammatory responses in LPS-stimulated RAW264.7 cells partly through inhibiting ERK1/2-，JNK-/PPAR-γ-stimulated NF-κB/AP-1/STAT-1 activations.[2] |
| Animal Experiment |
The phenotype of mice was recorded in the DSS-induced and/or alliin(500 mg/kg)groups. Histopathological alterations were analyzed by H&E staining. MPO and MDA of colon tissues were measured. The mRNA expression levels of inflammatory factors were determined by qRT-PCR，and protein expressions of inflammatory factors or activation of kinases were determined by Western blotting.[2] |
| Data Literature Source |
[1]. Lu J，et al. Alliin attenuates 1，3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway. Life Sci. 2018 Feb 15;195:19-24.
[2]. Shi L，et al. Alliin，a garlic organosulfur compound，ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-γ activation. Mol Nutr Food Res. 2017 Sep;61(9). |
| Unit |
Piece |
| Specification |
5mg 10mg 20mg |
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