| CAS |
464-92-6 |
| Chinese Name |
积雪草酸 |
| English Name |
Asiatic acid |
| Synonyms |
Dammarolic acid |
| Molecular Formula |
C30H48O5 |
| Molecular Weight |
488.7 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 482-720-9 |
| MDL |
MFCD00238541 |
| SMILES |
O=C([C@]12CC[C@@H](C)[C@H](C)[C@@]1([H])C3=CC[C@]4([H])[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@]5([H])CC[C@@]4(C)[C@]3(C)CC2)O |
| InChIKey |
JXSVIVRDWWRQRT-UYDOISQJSA-N |
| InChI |
InChI=1S/C30H48O5/c1-17-9-12-30(25(34)35)14-13-28(5)19(23(30)18(17)2)7-8-22-26(3)15-20(32)24(33)27(4,16-31)21(26)10-11-29(22,28)6/h7,17-18,20-24,31-33H,8-16H2,1-6H3,(H,34,35)/t17-,18+,20-,21-,22-,23+,24+,26+,27+,28-,29-,30+/m1/s |
| PubChem CID |
119034 |
| Target Point |
p38MAPK |
| Passage |
MAPK |
| Background |
It is a pentacyclic triterpenoid that induces apoptosis in melanoma cells. Also has anti-inflammatory activity. |
| Biological Activity |
Asiatic acid， a pentacyclic triterpene found in Centella asiatica， induces apoptosis in melanoma cells. Asiatic acid has the potential for skin cancer treatment[1]. Asiatic acid also has anti-inflammatory activities[2]. |
| In Vitro |
AA decreased viability and induced apoptosis in human melanoma SK-MEL-2 cells in a time- and dose-dependent manner. AA also markedly increased intracellular reactive oxygen species(ROS)level and enhanced the expression of Bax but not Bcl-2 protein in the cells. In addition，AA-induced activation of caspase-3 activity in a dose-dependent manner.[1] |
| In Vivo |
Treatment of male ICR mice with AA significantly inhibited the numbers of acetic acid-induced writhing responses and the formalin-induced pain in the late phase. In the anti-inflammatory test，AA decreased the paw edema at the 4th and 5th h after λ-carrageenan(Carr)administration and increased the activities of catalase(CAT)，superoxide dismutase(SOD)，and glutathione peroxidase(GPx)in the liver tissue. AA decreased the nitric oxide(NO)，tumor necrosis factor-α(TNF-α)，and interleukin-1β(IL-1β)levels on serum level at the 5th h after Carr injection. Western blotting revealed that AA decreased Carr-induced inducible nitric oxide synthase(iNOS)，cyclooxygenase(COX-2)，and nuclear factor-κB(NF-κB)expressions at the 5th h in the edema paw. An intraperitoneal(i.p.)injection treatment with AA also diminished neutrophil infiltration into sites of inflammation as did indomethacin(Indo).[2] |
| Data Literature Source |
[1]. Park BC，et al. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 2005 Jan 31;218(1):81-90.
[2]. Huang SS，et al. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. Evid Based Complement Alternat Med. 2011;2011:895857. |
| Unit |
Bottle |
| Specification |
5mg 10mM*1mL in DMSO 10mg 20mg |
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