| CAS |
67979-25-3 |
| Chinese Name |
橙黄决明素 |
| English Name |
Aurantio-obtusin |
| Synonyms |
1,3,7-trihydroxy-2,8-dimethoxy-6-methylanthracene-9,10-dione |
| Molecular Formula |
C17H14O7 |
| Molecular Weight |
330.29 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
Light yellow to yellow Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD13194886 |
| SMILES |
O=C1C2=C(C=C(C)C(O)=C2OC)C(C3=CC(O)=C(OC)C(O)=C13)=O |
| InChIKey |
RNXZPKOEJUFJON-UHFFFAOYSA-N |
| InChI |
InChI=1S/C17H14O7/c1-6-4-7-11(17(24-3)12(6)19)14(21)10-8(13(7)20)5-9(18)16(23-2)15(10)22/h4-5,18-19,22H,1-3H3 |
| PubChem CID |
155011 |
| Target Point |
Others |
| Passage |
Others |
| Background |
It is an anthraquinone compound. |
| Biological Activity |
Aurantio-obtusin， an anthraquinone compound， isolated from dried seeds of Cassia obtusifolia L. (syn. Senna obtusifolia; Fabaceae) and Cassia tora L. (syn. Senna tora). Aurantio-obtusin possesses hypotensive and hypolipidemic effects. Aurantio-obtusin was dependent on endothelium integrity and NO production， which mediated by endothelial PI3K/Akt/eNOS pathway. [1-2] |
| In Vitro |
Aurantio-obtusin significantly decreased the production of NO，PGE ，and inhibited the protein expression of COX-2，TNF-α and IL-6，which were similar to those gene expression of iNOS，COX-2，TNF-α and IL-6(p < 0.01). Consistent with the pro-inflammatory gene expression，the Aurantio-obtusin efficiently reduced the LPS-induced activation of nuclear factor-κB in RAW264.7 cells.[1] |
| In Vivo |
Aurantio-obtusin elicited dose-dependent vasorelaxation with phenylephrine(PE)precontracted rat MA rings(diameter: 200-300 μm)，which can be diminished by denudation of endothelium and inhibition of eNOS activity，while having no effect on rat isolated pulmonary artery(PA)rings.[2] |
| Data Literature Source |
[1]. Hou J，et al. Anti-Inflammatory Effects of Aurantio-Obtusin from Seed of Cassia obtusifolia L. through Modulation of the NF-κB Pathway. Molecules. 2018 Nov 27;23(12).
[2]. Li S，et al. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats. J Pharmacol Sci. 2015 Jul;128(3):108-15. |
| Unit |
Bottle |
| Specification |
1mg 5mg |
English
中文
Manual Download
