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Apigenin-7-O-glucronide

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Cat.No：IA1250 Solarbio

CAS：29741-09-1

Molecular Formula：C₂₁H₁₈O₁₁

Molecular Weight：446.36

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	29741-09-1
Name	Apigenin-7-O-glucronide
Molecular Formula	C₂₁H₁₈O₁₁
Molecular Weight	446.36
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD23699539
SMILES	O[C@H]([C@H]([C@@H]([C@@H](C(O)=O)O1)O)O)[C@@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C=C4)OC3=C2)=O
InChIKey	JBFOLLJCGUCDQP-ZFORQUDYSA-N
InChI	InChI=1S/C21H18O11/c22-9-3-1-8(2-4-9)13-7-12(24)15-11(23)5-10(6-14(15)31-13)30-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21-23,25-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1
PubChem CID	5319484
Target Point	MMP
Passage	Metabolic Enzyme&Protease
Background	It inhibits the activity of matrix metalloproteinases (MMPs).
Biological Activity	Apigenin-7-glucuronide 能够抑制基质金属蛋白酶 (MMP) 的活性，其对 MMP-3，MMP-8，MMP-9，MMP-13 的IC50 值分别为 12.87，22.39，17.52，0.27 μM。[1-2]
IC50	MMP-3:12.87μM;mMP-8:22.39μM;mMP-9:17.52μM;mMP13:0.27μM [1-2]
Data Literature Source	[1]. Crascì L，et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911. [2]. Deng W，et al. Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomed Pharmacother. 2018 Nov;107:1505-1513.
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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