| CAS |
27548-93-2 |
| Chinese Name |
巴卡亭 Ⅲ |
| English Name |
Baccatin Ⅲ |
| Synonyms |
巴卡丁Ⅲ;浆果赤霉素Ⅲ |
| Molecular Formula |
C31H38O11 |
| Molecular Weight |
586.63 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL |
MFCD00153921 |
| SMILES |
O=C1[C@H](OC(C)=O)C(C2(C)C)=C(C)[C@@H](O)C[C@@]2(O)[C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]1(C)[C@@H](O)C[C@@]5([H])OC[C@]54OC(C)=O |
| InChIKey |
OVMSOCFBDVBLFW-VHLOTGQHSA-N |
| InChI |
InChI=1S/C31H38O11/c1-15-19(34)13-31(38)26(41-27(37)18-10-8-7-9-11-18)24-29(6,20(35)12-21-30(24,14-39-21)42-17(3)33)25(36)23(40-16(2)32)22(15)28(31,4)5/h7-11,19-21,23-24,26,34-35,38H,12-14H2,1-6H3/t19-,20-,21+,23+,24-,26-,29+,30-,31+/m0/s1 |
| PubChem CID |
65366 |
| Target Point |
Others |
| Passage |
Others |
| Background |
Baccatin III can delay tumor progression by reducing the accumulation of MDSCs and inhibiting their function. |
| Biological Activity |
Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs[1]. |
| In Vivo |
MDSCs isolated from baccatin III-treated mice，compared with those isolated from vehicle-treated mice，had a significantly reduced suppressive effect on T cells treated with the anti-CD3 and anti-CD28 monoclonal antibodies. Baccatin III reduced tumor progression by inhibiting the accumulation and suppressive function of MDSCs.[1] |
| Cell Experiment |
Baccatin III，which is the precursor for the semisynthesis of paclitaxel，exerts anti-tumor immunomodulatory activity in very low doses(0.05-0.5mg/kg). Oral administration of baccatin III significantly reduced the growth of tumors induced by engrafting BALB/c mice with either 4 T1 mammary carcinoma or CT26 colon cancer cells. Baccatin III decreased the accumulation of MDSCs in the spleens of the tumor-bearing mice.[1] |
| Data Literature Source |
[1]. Lee YH，et al. Baccatin III，a precursor for the semisynthesis of paclitaxel，inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014 Aug;21(2):487-93. |
| Unit |
Bottle |
| Specification |
5mg 10mM*1mL in DMSO 10mg 20mg |
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