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My CartCAS：1135-24-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Off-white to yellow Solid
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| CAS | 1135-24-6 |
| Name | Ferulic acid |
| Molecular Formula | C10H10O4 |
| Molecular Weight | 194.19 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Ethanol ≥25mg/mL |
| Purity | HPLC≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-679-7 |
| MDL | MFCD00004400 |
| SMILES | O=C(O)/C=C/C1=CC=C(O)C(OC)=C1 |
| Target Point | FGFR |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor. |
| Biological Activity | Ferulic acid 是一种新型的成纤维细胞生长因子受体 1 (FGFR1) 抑制剂, 对于 FGFR1 和 FGFR2 的 IC50值分别为 3.78 and 12.5 μM。[1-2] |
| In Vitro | 阿魏酸对FGFR1表现出很强的抑制活性，在1μM时抑制率为92％。在阿魏酸处理5至40μM，持续24小时后，FGF1刺激的HUVEC增殖显著降低。阿魏酸在高达20μM时不会发挥显著的细胞活力，但超过30μM阿魏酸与对照相比在HUVEC中表现出细胞毒性作用。阿魏酸以剂量依赖性方式抑制FGF1诱导的HUVEC迁移和侵袭。阿魏酸显著抑制FGF1诱导的PI3K和Akt的磷酸化。阿魏酸处理显著抑制FGF1刺激的MMP-2和MMP-9表达[1]。 |
| In Vivo | 用阿魏酸(FA)治疗有效抑制FGF1诱导的新血管形成。发现与用DMSO处理的对应物相比，胃酸给予阿魏酸显著抑制肿瘤体积和肿瘤重量。此外，阿魏酸治疗耐受性良好，载体组和FA治疗组之间的体重没有显著差异[1]。通过口服途径给予的阿魏酸(0.01，0.1，1或10mg/kg)显著降低了强迫游泳试验(FST)和尾部悬吊试验(TST)中的不动时间，而在开放场试验中没有产生影响。结果表明阿魏酸(0.001 mg/kg，po)的施用增强了氟西汀(5 mg/kg，po)在TST中的抗抑郁样作用[2]。 |
| Cell Experiment | 将HUVEC(5×10 4个细胞/孔)接种到凝胶化的24孔培养板上，并在含有15％FBS的ECGS中培养。用DMSO(0.1％)或不同浓度的阿魏酸(FA)(0，2.5，5，10，20，30，40μM)处理HUVEC 24小时。通过MTT测定确定细胞活力。孵育4小时后，用酶标仪在450nm处测量吸光度。结果由每个实验的六个重复计算。进行了三次独立实验[1]。 |
| Animal Experiment | 将雄性瑞士小鼠(30至40g)维持在21至23℃，在12:12小时光照/黑暗循环(在07:00小时点亮)下自由获取水和食物。所有操作均在9:00至16:00之间进行，每只动物仅使用一次。为了研究阿魏酸的抗抑郁样作用，阿魏酸在0.001至10mg/kg的剂量范围内，通过口服途径(po)在强迫游泳试验(FST)前60分钟，尾悬浮试验(TST)或开放式现场测试。对照动物接受适当的载体[2]。 |
| Data Literature Source | [1]. Yang GW，et al. Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis. Int J Mol Sci. 2015 Oct 12;16(10):24011-31. [2]. Zeni AL，et al. Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: evidence for the involvement of the serotonergic system. Eur J Pharmacol. 2012 Mar 15;679(1-3):68-74. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in DMSO 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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