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Gramine

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Cat.No：IG0750 Solarbio

CAS：87-52-5

Molecular Formula：C₁₁H₁₄N₂

Molecular Weight：174.24

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	87-52-5
Name	Gramine
Molecular Formula	C₁₁H₁₄N₂
Molecular Weight	174.24
Solubility	Soluble in DMSO
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 201-749-8
MDL	MFCD00005629
SMILES	CN(C)CC1=CNC2=C1C=CC=C2
InChIKey	OCDGBSUVYYVKQZ-UHFFFAOYSA-N
InChI	InChI=1S/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3
PubChem CID	6890
Target Point	Adiponectin Receptor
Passage	GPCR & G Protein
Background	It is a potent adiponectin receptor (AdipoR) agonist.
Biological Activity	Gramine为有效的Adiponectin receptor (AdipoR)) 激动剂，对 AdipoR2 和 AdipoR1 的 IC50 值分别为 3.2 和 4.2 μM[1]。Gramine 具有抗肿瘤、抗炎和抗病毒作用[1]。Gramine 同时为小鼠和人 β2-Adrenergic receptor (β2-AR) 激动剂[2]。
IC50	3.2μM(AdipoR2)，4.2μM(AdipoR1)[1]
Data Literature Source	[1]. Sun Y，et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354. [2]. Chikazawa M，et al. Identification of Functional Food Factors as β2-Adrenergic Receptor Agonists and Their Potential Roles in Skeletal Muscle. J Nutr Sci Vitaminol (Tokyo). 2018;64(1):68-74.
Unit	Bottle
Specification	20mg 10mM*1mL in DMSO 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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