| CAS |
537-73-5 |
| Chinese Name |
异阿魏酸 |
| English Name |
3-Hydroxy-4-methoxycinnamic acid |
| Synonyms |
Hesperetate;Isoferulate |
| Molecular Formula |
C10H10O4 |
| Molecular Weight |
194.18 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
White to off-white Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 208-676-0 |
| MDL |
MFCD00004391 |
| SMILES |
O=C(O)/C=C/C1=CC=C(OC)C(O)=C1 |
| InChIKey |
QURCVMIEKCOAJU-HWKANZROSA-N |
| InChI |
InChI=1S/C10H10O4/c1-14-9-4-2-7(6-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+ |
| PubChem CID |
736186 |
| Target Point |
Adrenergic Receptor |
| Passage |
Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background |
3-Hydroxy-4-methoxycinnamic acid is a cinnamic acid derivative that binds and activates α1-adrenergic receptors, enhances β-endorphin secretion and increases glucose use in vitro. |
| Biological Activity |
Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 μM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use. Isoferulic acid also has anti-influenza virus activities.[1-2] |
| In Vitro |
Isoferulic acid(IFA)is a main active ingredient of the rhizoma of Cimicifuga beracleifolia，which is used frequently in Japanese traditional medicine as an anti-inflammatory drug. It has been revealed that IFA inhibits the production of macrophage inflammatory protein-2(MIP-2)，which is a murine counterpart of the chemokine family that may contribute to the pathogenesis of inflammatory diseases through the chemotactic activity for inflammatory and immune effector cells.[2] |
| In Vivo |
Isoferulic acid may activate alpha1-adrenoceptors to enhance the secretion of beta-endorphin，which can stimulate the opioid mu-receptors to increase glucose use or/and reduce hepatic gluconeogenesis，resulting in a decrease of plasma glucose in STZ-diabetic rats.[1] IFA administration markedly improved the survival rate and body weight loss of influenza virus-infected mice in a suitable dose range(0.5 mg/day).[2] |
| Animal Experiment |
Mice were infected by intranasal inoculation of influenza virus under ether anesthesia. The IFA or DX was given by oral administration once daily for 4 days after infection. After infection，the survival rate and the change in body weight were daily monitored.[2] |
| Data Literature Source |
[1]. Liu IM，et al. Mediation of beta-endorphin by isoferulic acid to lower plasma glucose in streptozotocin-induced diabetic rats. J Pharmacol Exp Ther. 2003 Dec;307(3):1196-204.
[2]. Sakai S，et al. Administration of isoferulic acid improved the survival rate of lethal influenza virus pneumonia in mice. Mediators Inflamm. 2001 Apr;10(2):93-6. |
| Unit |
Bottle |
| Specification |
20mg 50mg 100mg |
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