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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > KoumineCAS：1358-76-5
Molecular Formula：C20H22N2O
Molecular Weight：306.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 1358-76-5 |
| Name | Koumine |
| Molecular Formula | C20H22N2O |
| Molecular Weight | 306.41 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11111448 |
| SMILES | C=C[C@]12[C@]3([H])C[C@@H]4C5=NC6=CC=CC=C6[C@@]51C[C@H](N(C)C2)[C@@]3([H])CO4 |
| Target Point | Others |
| Passage | Others |
| Background | Koumine is an alkaloid in Gelsemium elegans with potent antitumor activity. |
| Biological Activity | Koumine 具有高效抗肿瘤活性，在肿瘤细胞中能够增加 Bax/Bcl-2 的蛋白比例和 caspase-3 的表达[1]。Koumine 具有抗焦虑、抗应激、抗银屑病和镇痛活性[3]。在类风湿性关节炎动物模型中，Koumine 能够预防关节炎的发展[2]。 |
| Data Literature Source | [1]. Zhang X，et al. Apoptotic Effect of Koumine on Human Breast Cancer Cells and the Mechanism Involved. Cell Biochem Biophys. 2015 Jun;72(2):411-6. [2]. Yang J，et al. Effects of Koumine on Adjuvant- and Collagen-Induced Arthritis in Rats. J Nat Prod. 2016 Oct 28;79(10):2635-2643. [3]. Jin GL，et al. Koumine Attenuates Neuroglia Activation and Inflammatory Response to Neuropathic Pain. Neural Plast. 2018 Mar 25;2018:9347696. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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