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Lycorine

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Cat.No：IL0520 Solarbio

CAS：476-28-8

Molecular Formula：C₁₆H₁₇NO₄

Molecular Weight：287.31

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	476-28-8
Name	Lycorine
Molecular Formula	C₁₆H₁₇NO₄
Molecular Weight	287.31
Solubility	Soluble in DMSO ≥10mg/mL
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 207-503-6
MDL	MFCD00221746
SMILES	O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4
Target Point	SCAP
Passage	Neuronal Signaling
Background	It is an effective SCAP inhibitor, down-regulating SCAP protein level without altering its transcription. It is also a melanoma angiogenesis inhibitor.
Biological Activity	Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription[1].
IC50	Kd: 15.24nM(SCAP)[1]
Data Literature Source	[1]. Zu-Guo Zheng，et al. Discovery of a Potent SCAP Degrader That Ameliorates HFD-induced Obesity，Hyperlipidemia and Insulin Resistance via an Autophagy-Independent Lysosomal Pathway. Autophagy. 2020 May 20;1-22.
Unit	Bottle
Specification	10mg 20mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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