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CAS:13063-04-2
Appearance:White to yellow solid
Storage:Powder : 2-8℃, 2 years
Purity:HPLC≥98%
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Examples of using this product（for reference only）
In Vivo：
Mice (4-5 week old BALB/c male mice; 8 or 16 mg/kg/week Nitidine chloride/NC，twice a day）：
H1688 cells or A549 cells (approximately 1× 107) were injected subcutaneously into the right fank of BALB/c mice. Considering that NC is poorly absorbed, we treated the mice with NC by intraperitoneal injection. Once the tumors volume reached an average of 50–80 mm3, the mice were randomized into 4 groups (n=5), with either vehicle control (0.1% DMSO), lower dose of NC (8 mg/kg/week), or higher dose of NC (16 mg/kg/week) twice a day respectively. As a positive control, mice were injected with DDP (8 mg/kg/week). Te tumor volume (length×width×width) and body weight of the mice were monitored every 2 days.
Reference：
Yu F, Tan W, Chen Z, Shen X, Mo X, Mo X, He J, Deng Z, Wang J, Luo Z, Yang J. Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer. Chin Med. 2022 Sep 29;17(1):115. doi: 10.1186/s13020-022-00671-y. PMID: 36175965; PMCID: PMC9524076.
