Products
Nitidine chloride

CAS:13063-04-2

Storage:Powder:2-8℃,2 years

Purity:HPLC≥98%

Appearance:White to yellow Solid

Nitidine chloride
Cat.No:
IN0430
Brand:
Solarbio
SKU Tongzhou Beijing Haidian Beijing Wuhan Guangzhou
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Examples of using this product(for reference only)

In Vivo:

Mice (4-5 week old BALB/c male mice; 8 or 16 mg/kg/week Nitidine chloride/NC,twice a day):

H1688 cells or A549 cells (approximately 1× 107) were injected subcutaneously into the right fank of BALB/c mice. Considering that NC is poorly absorbed, we treated the mice with NC by intraperitoneal injection. Once the tumors volume reached an average of 50–80 mm3, the mice were randomized into 4 groups (n=5), with either vehicle control (0.1% DMSO), lower dose of NC (8 mg/kg/week), or higher dose of NC (16 mg/kg/week) twice a day respectively. As a positive control, mice were injected with DDP (8 mg/kg/week). Te tumor volume (length×width×width) and body weight of the mice were monitored every 2 days.

Reference:

Yu F, Tan W, Chen Z, Shen X, Mo X, Mo X, He J, Deng Z, Wang J, Luo Z, Yang J. Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer. Chin Med. 2022 Sep 29;17(1):115. doi: 10.1186/s13020-022-00671-y. PMID: 36175965; PMCID: PMC9524076.

Remark:
These protocols are for reference only. Solarbio does not independently validate these methods.

Note:
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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