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Oridonin

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Cat.No：IO0230 Solarbio

CAS：28957-04-2

Molecular Formula：C₂₀H₂₈O₆

Molecular Weight：364.43

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	28957-04-2
Name	Oridonin
Molecular Formula	C₂₀H₂₈O₆
Molecular Weight	364.43
Solubility	Soluble in DMSO ≥10mg/mL
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00221762
SMILES	O[C@@H]1[C@]2(CO3)[C@@]([C@H](O)[C@]3(O)[C@]45[C@@]2([H])CC[C@](C(C5=O)=C)([H])[C@@]4([H])O)([H])C(C)(C)CC1
Target Point	Akt
Passage	PI3K/Akt/mTOR
Background	It is an AKT inhibitor with anti-tumor, antibacterial, anti-inflammatory and other physiological activities, which can be used for related research.
Biological Activity	Oridonin 是从 Rabdosia rubescens 中得到的二萜，为 AKT 抑制剂，对 AKT1 和 AKT2 的 IC50 值分别为 8.4 和 8.9 μM；Oridonin 具有抗肿瘤、抗菌、抗炎等功效。[1-2]
IC50	Akt1:8.4μM;Akt2:8.9μM [1]
Data Literature Source	[1]. Song M，et al. Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo. Mol Cancer Ther. 2018 Apr 25. pii: molcanther.0823.2017. [2]. Sun B，et al. Oridonin inhibits aberrant AKT activation in breast cancer. Oncotarget. 2018 Feb 1;9(35):23878-23889
Unit	Bottle
Specification	10mg 10mM*1mL in DMSO 20mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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