| CAS |
29700-22-9 |
| Chinese Name |
氧化白藜芦醇 |
| English Name |
Oxyresveratrol |
| Synonyms |
4-[(E)-2-(3,5-二羟基苯基)乙烯基]苯-1,3-二醇;2,4,3',5'-四羟基二苯乙烯;2,4,3',5'-四羟基 |
| Molecular Formula |
C14H12O4 |
| Molecular Weight |
244.24 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
White to yellow Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 300-008-4 |
| MDL |
MFCD11974969 |
| SMILES |
OC1=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C(O)=C1 |
| Target Point |
Tyrosinase |
| Passage |
Metabolic Enzyme&Protease |
| Background |
It is a compound with neuroprotective activity. |
| Biological Activity |
Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1， HSV-2 and varicella-zoster virus， and has neuroprotective effects.Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). [1-4]. |
| IC50 |
1.2μM(Mushroom tyrosinase)[2] |
| In Vitro |
Cultures of the murine microglial cell line N9 and primary mixed glial cultures were used to test the drug effects of NO production upon expression of the inducible isoform of nitric oxide synthase(iNOS). Oxyresveratrol considerably diminished NO(nitrite)levels(IC50 of 45.31 μM)in murine microglial cells.Oxyresveratrol can inhibit DOPA oxidase activity，cyclooxygenase，and rat liver mitochondrial ATPase activity[1].Oxyresveratrol exhibits 63.3% inhibition at 100 μM and an IC50 value of 52.7 μM on the murine tyrosinase activity.Oxyresveratrol exhibits a dose-dependent inhibitory effect on L-tyrosine oxidation by the murine tyrosinase but does not inhibit the promoter activity of the enzyme gene. Oxyresveratrol exhibits significant inhibitory effects at 10 μM and higher concentrations on murine tyrosinase activity[2]. |
| In Vivo |
Oxyresveratrol(2-30 mg/kg; intraperitoneal injection; twice)treatment reduces the brain infarct volume in MCAO rats. Oxyresveratrol treatment diminishes cytochrome c release and decreased caspase-3 activation，and reduces the number of apoptotic nuclei in ischemic brain in MCAO rats[3]. |
| Data Literature Source |
[1]. Lorenz. et al. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: Effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide 9(2) 64-76 (2003).
[2]. Kim，Y.M.，Yun，J.，Lee，C.，et al. Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of action. J Biol Chem277(18) 16340-16344 (2002).
[3]. Shaida A Andrabi et al. Oxyresveratrol (trans-2，3′，4，5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Res，2004 Aug 13，1017(1-2):98-107.
[4]. Vimolmas Lipipun，et al. Topical cream-based oxyresveratrol in the treatment of cutaneous HSV-1 infection in mice. Antiviral Res. 2011 Aug;91(2):154-60. |
| Unit |
Bottle |
| Specification |
50mg 10mM*1mL in DMSO 100mg |
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