CAS |
83-86-3 |
Chinese Name |
植酸 |
English Name |
Phytic acid |
Synonyms |
Inositol hexaphosphate;inositol polyphosphate;inositol hexakisphosphate;Fytic Acid |
Molecular Formula |
C6H18O24P6 |
Molecular Weight |
660.04 |
Solubility |
Soluble in Water |
Purity |
HPLC≥98% |
Appearance |
White to off-white Solid |
Storage |
Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC |
EINECS 201-506-6 |
MDL |
MFCD00082309 |
SMILES |
O=P(O)(O)O[C@H]([C@H]([C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O)OP(O)(O)=O)[C@H]([C@H]1OP(O)(O)=O)OP(O)(O)=O |
InChIKey |
IMQLKJBTEOYOSI-UHFFFAOYSA-N |
InChI |
InChI=1S/C6H18O24P6/c7-31(8,9)25-1-2(26-32(10,11)12)4(28-34(16,17)18)6(30-36(22,23)24)5(29-35(19,20)21)3(1)27-33(13,14)15/h1-6H,(H2,7,8,9)(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)(H2,19,20,21)(H2,22,23,24) |
PubChem CID |
890 |
Target Point |
Xanthine Oxidase(XO) |
Passage |
Metabolic Enzyme&Protease |
Background |
Phytic acid is the main phosphorus storage compound in most seeds and grains. |
Biological Activity |
Phytic acid是大多数种子和谷物的主要磷储存化合物。[1-4] |
In Vitro |
植酸是大多数种子和谷物的主要磷储存化合物,占其干重的约1%至7%。它可能占总核磷的70%以上。植酸具有很强的螯合多价金属离子的能力,尤其是锌,钙和铁。结合可导致非常不溶的盐,其从胃肠道吸收差,这导致矿物质的生物利用度差。植酸也被认为是一种天然抗氧化剂,被认为具有降低脂质过氧化的潜在功能,并且作为食品中的防腐剂[1]。植酸抑制黄嘌呤中尿酸的形成,IC50为约30mM。植酸对超氧化物的产生有很大影响; IC50约为6 mM,表明XO的超氧化物生成区域对植酸更敏感[2]。已经观察到在少数癌细胞系(包括结肠,乳头,乳腺,前列腺,子宫颈,肝脏,胰腺,黑素瘤和胶质母细胞瘤)中存在植酸的肿瘤生长抑制和细胞分化诱导[3]。 |
In Vivo |
植酸在MPTP诱导的PD模型中具有神经保护作用,并且神经保护作用与其抗炎作用相关,其可能与抑制涉及NF-κB和p-ERK的途径有关。植酸显着抑制MPTP诱导的黑质(SN)中的多巴胺能细胞损失。此外,使用免疫组织化学方法和定量聚合酶链反应(qPCR),发现小胶质细胞激活和诱导型一氧化氮合酶(iNOS)被植酸显着抑制[4]。 |
Animal Experiment |
小鼠:施用MPTP(20mg / kg /天,腹膜内注射)5天,并在7天后杀死动物。在MPTP给药前4天注射植酸(30mg / kg /天,ip)或正常盐水,并持续至小鼠被杀死,达到16天的总治疗期[4]。 |
Data Literature Source |
[1]. Zhou JR, et al. Phytic acid in health and disease. Crit Rev Food Sci Nutr. 1995 Nov; 35 (6) :495-508. [2]. Muraoka S, et al. Inhibition of xanthine oxidase by phytic acid and its antioxidative action. Life Sci. 2004 Feb 13; 74 (13) :1691-700. [3]. Nawrocka-Musial D, et al. Phytic acid--anticancer nutriceutic. Pol Merkur Lekarski. 2012 Jul; 33 (193) :43-7. [4]. Lv Y, et al. Phytic acid attenuates inflammatory responses and the levels of NF-κB and p-ERK in MPTP-induced Parkinson's disease model of mice. Neurosci Lett. 2015 Jun 15; 597:132-6. |
Unit |
Bottle |
Specification |
100mg 10mM*1mL in Water 500mg |