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Piperine

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Cat.No：IP0750 Solarbio

CAS：94-62-2

Molecular Formula：C₁₇H₁₉NO₃

Molecular Weight：285.34

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：HPLC≥98%

Appearance：White to off-white Solid

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Product Information

CAS	94-62-2
Name	Piperine
Molecular Formula	C₁₇H₁₉NO₃
Molecular Weight	285.34
Solubility	Soluble in DMSO ≥10mg/mL
Purity	HPLC≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 202-348-0
MDL	MFCD00005839
SMILES	O=C(N1CCCCC1)/C=C/C=C/C2=CC=C(OCO3)C3=C2
Target Point	P-gp(P-glycoprotein)
Passage	Membrane Transporter&Ion Channel
Background	Piperine can inhibit the activity of P-glycoprotein and CYP3A4.
Biological Activity	Piperine是从胡椒中分离的天然生物碱，可以抑制P-glycoprotein and CYP3A4的活性，在HeLa细胞中的IC50值为61.94±0.054 μg/mL。[1-4]
IC50	61.94±0.054μg/mL(P-glycoprotein，HeLa cell)[1]
Data Literature Source	[1]. Paarakh PM，et al. In vitro cytotoxic and in silico activity of piperine isolated from Piper nigrum fruits Linn. In Silico Pharmacol. 2015 Dec;3(1):9. Epub 2015 Oct 29. [2]. Meghwal M，et al. Piper nigrum and piperine: an update. Phytother Res. 2013 Aug;27(8):1121-30. [3]. Li C，et al. Non-linear pharmacokinetics of piperine and its herb-drug interactions with docetaxel in Sprague-Dawley rats. J Pharm Biomed Anal. 2016 Sep 5;128:286-93. [4]. Zhai WJ，et al. Piperine Plays an Anti-Inflammatory Role in Staphylococcus aureus Endometritis by Inhibiting Activation of NF-κB and MAPK Pathways in Mice. Evid Based Complement Alternat Med. 2016;2016:8597208.
Unit	Bottle
Specification	100mg 10mM*1mL in DMSO 500mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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