CAS |
20874-52-6 |
Chinese Name |
柴胡皂苷D |
English Name |
Saikosaponin D |
Synonym |
柴胡皂苷D;SaikosaponinBII;Saikosaponinb2std.;SaikosaponianD; |
Purity |
HPLC≥98% |
Unit |
Bottle |
Molecular Formula |
C42H68O13 |
Molecular Weight |
780.98 |
Appearance |
White to off-white solid |
Storage |
Powder : 2-8℃, 2 years; In solvent(mother liquid): -20℃, 1 month; -80℃, 6 months |
Solubility |
Soluble in DMSO |
MDL |
MFCD09028095 |
SMILES |
CC1(C)CC[C@]2(CO3)[C@H](O)C[C@@]4(C)[C@]([C@]5([H])C=C[C@]43[C@]2([H])C1)(C)CC[C@@]([C@]5(C)CC6)([H])[C@@](CO)(C)[C@H]6O[C@@](O[C@H](C)[C@@H]7O)([H])[C@H](O)[C@H]7O[C@@]8([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8 |
Description |
Saikosaponin D is a triterpenoid saponin from Bupleurum chinense, which has anti-inflammatory, antibacterial, anti-tumor and anti-allergic activities. Saikosaponin D is a new SERCA inhibitor. |
Target Point |
SERCA |
Passage |
Membrane Transporter&Ion Channel |
Data Literature Source |
[1]. Jang MJ, et al. Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion. Molecules. 2014 Dec 4;19(12):20340-9.
[2]. Liu A, et al. Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling. Chem Biol Interact. 2014 Nov 5;223:80-6.
[3]. Que R, et al. Estrogen receptor-β-dependent effects of saikosaponin‑d on the suppression of oxidative stress-induced rat hepatic stellate cell activation. Int J Mol Med. 2018 Mar;41(3):1357-1364.
[4]. Wong VK, Li T, Law BY, Ma ED, Yip NC, Michelangeli F, Law CK, Zhang MM, Lam KY, Chan PL, Liu L. Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells. Cell Death Dis. 2013 Jul 11;4(7):e720. |
Specification |
5mg 10mM*1mL in DMSO 10mg 20mg |