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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Tanshinone IIA-sulfonic sodiumCAS：69659-80-9
Molecular Formula：C19H17O6S·Na
Molecular Weight：396.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Red Solid
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| CAS | 69659-80-9 |
| Name | Tanshinone IIA-sulfonic sodium |
| Molecular Formula | C19H17O6S·Na |
| Molecular Weight | 396.39 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | Red Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09028094 |
| SMILES | O=S(C1=C(C)C(C(C(C2=C3C=CC4=C2CCCC4(C)C)=O)=O)=C3O1)([O-])=O.[Na+] |
| Target Point | SOCE |
| Passage | Membrane Transporter&Ion Channel |
| Background | Tanshinone IIA sulfonate sodium is a derivative of tanshinone IIA, an inhibitor of SOCE, which can be used in cardiovascular disease related research. |
| Biological Activity | Tanshinone IIA sulfonate sodium 是 tanshinone IIA 的水溶衍生物，为 SOCE 的抑制剂，用于治疗心血管疾病。[1-5] |
| Data Literature Source | [1]. Xu QQ，et al. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. Biomed Res Int. 2016;2016:9852536. [2]. Jiang Q，et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C136-49. [3]. Ouyang DS，et al. Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chin Med. 2016 Mar 22;11:11. [4]. Chen D，et al. Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica. 2016 Dec;46(12):1085-1092. Epub 2016 Mar 2. [5]. Lin S，et al. [Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):260-4. |
| Unit | Bottle |
| Specification | 20mg 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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Han D, Wu X, Liu L, Shu W, Huang Z. Sci Rep. 2018 Oct 11;8(1):15137. doi: 10.1038/s41598-018-33552-2.
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Sodium tanshinone IIA sulfonate protects ARPE-19 cells against oxidative stress by inhibiting autophagy and apoptosis
Click to check >>Author：Han D; Wu X; Liu L; Shu W; Huang Z
IF：4.9960
Publish_to：Sci Rep
PMID：30310136
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